The first time you load an assembly of Quartz.NET jobs, it populates the database with the current trigger information (cron vs. simple, timings, etc.) that it finds in the configuration file. It appears that this information does not get updated once it's in the database. So if you want to make a change to set the trigger time to be every minute instead of the original version of "run every day at 2am", you will be waiting for a loooong time to see that trigger fire (unless you start at 1:59am :)).
Since I'm using Migrator.NET to control my database schema, I can easily drop the tables and recreate them. This isn't a big deal because once I have things tested, I won't need to change the trigger information, but it did trip me up for a bit so I thought I'd share.
Disclaimer The opinions expressed herein are my own personal opinions and do not represent my employer's view in any way.