On my desktop machine, I have a dual monitor setup with 2 19" monitors and an ATI Radeon graphic card running each monitor at 1152x864. This setup has worked flawlessly for me for a couple of years. Recently, though, my primary monitor has been acting up. When I first boot up, I need to move my mouse, which then "scrolls" the viewable area. It's like I have a virtual desktop with the size of my monitor set too small for the resolution at which I'm running.
I dug around on the Display Properties' Advanced setup and went to my video card's control center. There, I noticed the EDID settings were claiming the maximum resolution of the monitor was 1024x768. That would explain this behavior. I disabled EDID for the problem monitor and set the value to the proper resolution (1600x1200). Everything is working great again.